“Pain is real when you get other people to believe in it. If no one believes in it but you, your pain is madness or hysteria”
-Naomi Wolfe (1991)

 

Visceral Pain

Visceral Pain: Quick Facts

  • Abdominal pain is the most common cause of an outpatient GI visit with nearly  16 million visits in 2009,  nearly  four times more than the next leading cause

 

  • It also accounts for nearly 4% of all visits to the emergency rooom. Yet, it's pathophysiological basis is poorly understood and there are no specific analgesic drugs

Our lab has developed novel models of visceral pain that advance knowledge about the neurobiology of pain and point towards novel therapeutic targets

Models of Pain in the Pasricha Lab

Our lab has pioneered the use of rodent (rats and mice) to model chronic abdominal pain syndromes that include:

  • Acute and chronic pancreatitis

  • Irritable bowel syndrome

  • Functional dyspepsia

 

Some novel therapeutic targets for visceral pain identified by the Pasricha lab:

  • PAR2 (protease activated receptor 2)

  • TGFbeta signaling

  • KCNA4 potassium channel